Author: Md. Humayan Kabir
Affiliation: Department of Pharmaceutical Technology, University of Asia Pacific.
This study evaluates whether publicly available pharmacovigilance systems contain the information required for comparative medication-safety research using target-trial principles. It combines a secondary analysis of global VigiBase aggregates with a cross-national audit of public safety-data architectures from major regulatory systems.
The analysis included 15,069,370 sex-coded reports
Author: Md. Humayan Kabir
Affiliation: Department of Pharmaceutical Technology, University of Asia Pacific.
This study proposes an integrated mechanistic generative-design framework for continuous pharmaceutical crystallization by combining explainable molecular graph generation, molecular-to-process property translation, computational fluid dynamics (CFD) digital twins, reduced-order surrogate modeling, process analytical technology, and constrained Bayesian optimization.
The framework was ev
Author: Md. Humayan Kabir
Affiliation: University of Asia Pacific.
This review introduces a redox-gated model for metal-based cancer therapy by integrating metal-drug speciation with tumor-specific ferroptosis susceptibility. The framework examines how blood-phase transformation, protein binding, intracellular localization, metal metabolism, lipid peroxidation pathways, and antioxidant defense systems influence therapeutic outcomes.
The study proposes patient stratification using a five-state
